Altered signalling from germline to intestine pushes daf-2;pept-1 Caenorhabditis elegans into extreme longevity
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منابع مشابه
Caenorhabditis elegans HCF-1 Functions in Longevity Maintenance as a DAF-16 Regulator
The transcription factor DAF-16/forkhead box O (FOXO) is a critical longevity determinant in diverse organisms, however the molecular basis of how its transcriptional activity is regulated remains largely unknown. We report that the Caenorhabditis elegans homolog of host cell factor 1 (HCF-1) represents a new longevity modulator and functions as a negative regulator of DAF-16. In C. elegans, hc...
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ژورنال
عنوان ژورنال: Aging Cell
سال: 2010
ISSN: 1474-9718,1474-9726
DOI: 10.1111/j.1474-9726.2010.00591.x